Está compuesto por 8 investigadores, 3 químicos y una secretaria.

Misión

La misión del Departamento de Inmunología es desarrollar investigación y proveer educación de la más alta calidad en los campos de la inflamación, la autoinmunidad y la inmunología general en cardiología y áreas afines.

Visión

La visión del Departamento de Inmunología es desarrollar investigación de frontera en los temas propios de su campo del conocimiento, fortalecer la colaboración con otros departamentos del Instituto y con otras instituciones, e incrementar la formación de estudiantes de posgrado, de manera que se consolide como un equipo de investigación básica, traslacional y clínica, capaz de aportar conocimiento útil en beneficio de los pacientes con patologías cardiacas y relacionadas.

Objetivos

Generar un ambiente propicio y optimizar los recursos institucionales para ofrecer las mejores condiciones posibles para:

  • Desarrollar investigación de alta calidad en los campos de inflamación, autoinmunidad e inmunología general en cardiología y áreas afines.
  • Proveer entrenamiento científico de posgrado para preparar individuos calificados para contribuir a profundizar el conocimiento de la participación de la inflamación y la inmunología en la patogénesis cardiaca y su resolución.
  • Buscar la interacción y colaboración entre distintas disciplinas del conocimiento y distintos enfoques clínicos y básicos para aproximarse a soluciones a los principales problemas de salud cardiaca.

Jefe del Departamento
Rafael Bojalil Parra
Grados Académicos: Maestría y Doctorado en Investigación Biomédica Básica
Nivel SNI: III
Nombramiento: Investigador en Ciencias Médicas “F”
Teléfono: Ext. 21310
Correo: rafaelbojalil@gmail.com

Secretaria
Leticia Espinosa Zaragoza
Teléfono: Ext. 21310
Correo: leticiaesp75@yahoo.com.mx

Químicos

Martha Ballinas Verdugo
Grados académicos: Maestría en Ciencias Químico Biológicas.
Nombramiento: Químico “B”
Teléfono: Ext. 21310
Correo: maalbave_64@yahoo.com

Valentín Jiménez Rojas
Nombramiento: Químico “A”
Teléfono: Ext. 21310
Correo: vajiro14@gmail.com

Martha Rios Castro
Nombramiento: Químico “A”
Teléfono: Ext. 21310
Correo: marthar8@hotmail.com

Investigadores

Luis Manuel Amezcua Guerra
Grados académicos: Especialidad en Medicina Interna, Subespecdialidad en
Reumatología, Doctorado en Ciencias Biológicas y de la Salud.
Nivel SNI: II
Nombramiento: Investigador en Ciencias Médicas “D”
Teléfono: Ext. 21310
Correo: lmamezcuag@gmail.com

Malinalli Brianza Padilla
Grados académicos: Mastría y Doctorado en Biología Experimental.
Nivel SNI: Candidato
Nombramiento: Ayudante de Investigador en Ciencias Médicas “C”
Teléfono: Ext. 21310
Correo: maly.brianz@gmail.com

Lorena Gómez García
Grados académicos: Doctorado en Ciencias Biomédicas.
Nivel SNI: I
Nombramiento: Investigador en Ciencias Médicas “D”
Teléfono: Ext. 21310
Correo: gomezlor@gmail.com

Ricardo Márquez Velasco
Grados académicos: Maestría en Biología Experimental y Doctorado en Ciencias
Biológicas.
Nivel SNI: I
Nombramiento: Investigador en Ciencias Médicas “D”
Teléfono: Ext. 21310
Correo: marquezric@hotmail.com

Fausto Sánchez Muñoz
Grado Académico: Maestría en Biología Experimental y Doctorado en Ciencias
Biológicas y de la Salud.
Nivel SNI: II
Nombramiento: Investigador en Ciencias Médicas “D”
Teléfono: Ext. 21310
Correo: fausto22@yahoo.com

María Elena Soto López
Grado Académico: Especialidad en Medicina Interna, Subespecialidad en
Reumatología, Maestría y Doctorado en Ciencias Médicas.
Nivel SNI: II
Nombramiento: Investigador en Ciencias Médicas “D”
Teléfono:
Correo: mesoto50@hotmail.com

Rashidi Springall del Villar
Grado Académico: Doctorado en Ciencias Biológicas.
Nombramiento: Investigador en Ciencias Médicas “C”
Teléfono: Ext. 21310
Correo: raspringall@yahoo.com

Líneas de Investigación

  • Enfermedad cardiovascular: Marcadores inflamatorios de utilidad clínica y resolución del proceso inflamatorio en síndromes coronarios agudos y enfermedad valvular, inmunopatología, síndromes aórticos, síncope vasovagal, relación con enfermedades metabólicas, quimiocinas ELR+.
  • Hipertensión pulmonar: Estrés por frío y expresión de genes de la vía de TGFb.
  • Expresión de microRNAs y otros genes de la respuesta inflamatoria.
  • Autoinmunidad y tejido conectivo: Lupus eritematoso sistémico, artritis reumatoide, síndrome de Sjögren, esclerosis sistémica, síndrome de anticuerpos antifosfolípidos, psoriasis, vasculitis, síndrome de Marfán y otras fibrilinopatías.
  • Sepsis polimicrobiana: Alteraciones inmunopatológicas en modelos múridos de endotoxemia.
  • Mediadores inflamatorios en hemoderivados y su efecto sobre la función celular.

Publicaciones últimos 5 años

1. Alemán-Ávila I, Jiménez-Morales M, Beltrán-Ramírez O, Barbosa-Cobos RE, Jiménez- Morales S, Sánchez-Muñoz F, Valencia-Pacheco G, Amezcua-Guerra LM, Juárez- Vicuña Y, Razo-Blanco Hernández DM, Aguilera-Cartas MC, López-Villanueva RF, Peralta-Zaragoza O, Tovilla-Zárate C, Ramírez-Bello J. Functional polymorphisms in pre-miR146a and pre-miR499 are associated with systemic lupus erythematosus but not with rheumatoid arthritis or Graves' disease in Mexican patients. Oncotarget. 2017 Jul 27;8(54):91876-91886.

2. Alexanderson-Rosas E, Monroy-Gonzalez AG, Juarez-Orozco LE, Martinez-Aguilar MM, Estrada E, Soldevilla I, Garcia-Pérez O, Soto-Lopez ME. [(18)F]-Sodium fluoride uptake in Takayasu arteritis. J Nucl Cardiol. 2017 Oct;24(5):1674-1679.

3. Amezcua-Guerra LM, Ferrusquía-Toriz D, Castillo-Martínez D, Márquez-Velasco R, Chávez-Rueda AK, Bojalil R. Limited effectiveness for the therapeutic blockade of interferon α in systemic lupus erythematosus: a possible role for type III interferons. Rheumatology (Oxford). 2015 Feb;54(2):203-5.

4. Amezcua-Guerra LM, Higuera-Ortiz V, Arteaga-García U, Gallegos-Nava S, Hübbe-
Tena C. Performance of the 2012 Systemic Lupus International Collaborating Clinics and the 1997 American College of Rheumatology classification criteria for systemic lupus erythematosus in a real-life scenario. Arthritis Care Res (Hoboken). 2015 Mar;67(3):437-41.

5. Amezcua-Guerra LM, Hofmann F, Vargas A, Rodriguez-Henriquez P, Solano C, Hernández-Díaz C, Castillo-Martinez D, Ventura-Ríos L, Gutiérrez M, Pineda C. Joint involvement in primary Sjögren's syndrome: an ultrasound "target area approach to arthritis". Biomed Res Int. 2013;2013:640265.

6. Amezcua-Guerra LM, Márquez-Velasco R, Chávez-Rueda AK, Castillo-Martínez D, Massó F, Páez A, Colín-Fuentes J, Bojalil R. Type III Interferons in Systemic Lupus Erythematosus: Association Between Interferon λ3, Disease Activity, and Anti-Ro/SSA Antibodies. J Clin Rheumatol. 2017 Oct;23(7):368-375.

7. Amezcua-Guerra LM. Improving definitions for an index of cumulative organ damage in patients with the antiphospholipid syndrome (DIAPS). Lupus. 2016 May;25(6):671-2

8. Arana-Ruiz JC, Amezcua-Guerra LM. Acro-osteolysis as an indicator of severity in systemic sclerosis. Reumatol Clin. 2016 Sep-Oct;12(5):263-6.

9. Arana-Ruiz JC, Silveira LH, Castillo-Martínez D, Amezcua-Guerra LM. Assessment of nailfold capillaries with a handheld dermatoscope may discriminate the extent of organ involvement in patients with systemic sclerosis. Clin Rheumatol. 2016 Feb;35(2):479-82.

10. Avendaño-Pérez L, Soto ME, Ávila-Vanzzini N, Bracamontes-Castelo G, Ruán Díaz JC, Alexanderson-Rosas E, Espinola-Zavaleta N. Mechanical deformation in adult patients with unrepaired aortic coarctation. Int J Cardiovasc Imaging. 2017 Nov 30. doi: 10.1007/s10554-017-1286-9.

11. Ballinas-Verdugo MA, Mejía-Domínguez AM, Sánchez-Guerrero SA, Lerma C, Martínez- Cruz M, Álvarez-Manilla-Toquero E, Jiménez-Díaz X, Barrera-Trujillo F, Ticante-Cruz MD, Estevez-Garcia IO, Amezcua-Guerra LM, Reyes-Lopez PA. The Type of Trypanosoma Cruzi Strain (Native or Non-Native) Used as Substrate for Immunoassays Influences the Ability of Screening Asymptomatic Blood Donors. Rev Invest Clin. 2016 Nov-Dec;68(6):286-291.

12. Barragan-Garcia O, Soto ME, Zamora KD, Lupi-Herrera E, Espinola-Zavaleta N.
Rheumatoid arthritis: A case of multivalvular heart disease. Arch Cardiol Mex. 2017 Jan - Mar;87(1):88-91.

13. Bikel S, Jacobo-Albavera L, Sánchez-Muñoz F, Cornejo-Granados F, Canizales- Quinteros S, Soberón X, Sotelo-Mundo RR, Del Río-Navarro BE, Mendoza-Vargas A, Sánchez F, Ochoa-Leyva A. A novel approach for human whole transcriptome analysis based on absolute gene expression of microarray data. PeerJ. 2017 Dec 8;5:e4133. doi: 10.7717/peerj.4133. eCollection 2017.

14. Bini EI, D'Attilio L, Marquina-Castillo B, Mata-Espinosa D, Díaz A, Marquez-Velasco R, Ramos-Espinosa O, Gamboa-Domínguez A, Bay ML, Hernández-Pando R, Bottasso O. The implication of pro-inflammatory cytokines in the impaired production of gonadal androgens by patients with pulmonary tuberculosis. Tuberculosis 2015; 95:701-6.

15. Binia A, Vargas-Martínez C, Ancira-Moreno M, Gosoniu LM, Montoliu I, Gámez-Valdez E, Soria-Contreras DC, Angeles-Quezada A, Gonzalez-Alberto R, Fernández S, Martínez-Conde D, Hernández-Morán B, Ramírez-Solano M, Pérez-Ortega C, Rodríguez-Carmona Y, Castan I, Rubio-Aliaga I, Vadillo-Ortega F, Márquez-Velasco R, Bojalil R, López-Alvarenga JC, Valet P, Kussmann M, Silva-Zolezzi I, Tejero ME. Improvement of cardiometabolic markers after fish oil intervention in young Mexican adults and the role of PPARα L162V and PPARγ2 P12A. J Nutr Biochem. 2017 May;43:98-106.

16. Bojalil R, Mata-González MT, Sánchez-Muñoz F, Yee Y, Argueta I, Bolaños L, Amezcua-Guerra LM, Camacho-Villegas TA, Sánchez-Castrejón E, García-Ubbelohde WJ, Licea-Navarro AF, Márquez-Velasco R, Paniagua-Solís JF. Anti-tumor necrosis factor VNAR single domains reduce lethality and regulate underlying inflammatory response in a murine model of endotoxic shock. BMC Immunol. 2013 Apr 2;14:17. doi: 10.1186/1471-2172-14-17.

17. Bongiovanni B, Mata-Espinosa D, D'Attilio L, Leon-Contreras JC, Marquez-Velasco R, Bottasso O, Hernandez-Pando R, Bay ML. Effect of cortisol and/or DHEA on THP1- derived macrophages infected with Mycobacterium tuberculosis. Tuberculosis 2015; 95:562-9.

18. Brianza-Padilla M, Bonilla-Jaime H, Almanza-Pérez JC, López-López AL, Sánchez- Muñoz F, Vázquez-Palacios G. Effects of different periods of paradoxical sleep deprivation and sleep recovery on lipid and glucose metabolism and appetite hormones in rats. Appl Physiol Nutr Metab. 2016 Mar;41(3):235-43.

19. Brianza-Padilla M, Carbó R, Arana JC, Vázquez-Palacios G, Ballinas-Verdugo MA, Cardoso-Saldaña GC, Palacio AG, Juárez-Vicuña Y, Sánchez F, Martínez-Martínez E, Huang F, Sánchez-Muñoz F, Bojalil R. Inflammation Related MicroRNAs Are Modulated in Total Plasma and in Extracellular Vesicles from Rats with Chronic Ingestion of Sucrose. Biomed Res Int. 2016;2016:2489479. doi: 10.1155/2016/2489479.

20. Castillo-Martínez D, Juarez M, Patlán M, Páez A, Massó F, Amezcua-Guerra LM. Type- III interferons and rheumatoid arthritis: Correlation between interferon lambda 1 (interleukin 29) and antimutated citrullinated vimentin antibody levels. Autoimmunity. 2017 Mar;50(2):82-85.

21. Castillo-Martínez D, Marroquín-Fabián E, Lozada-Navarro AC, Mora-Ramírez M, Juárez M, Sánchez-Muñoz F, Vargas-Barrón J, Sandoval J, Amezcua-Guerra LM. Levels of uric acid may predict the future development of pulmonary hypertension in systemic lupus erythematosus: a seven-year follow-up study. Lupus. 2016 Jan;25(1):61-6.

22. Cetina L, Crombet T, Jiménez-Lima R, Zapata S, Ramos M, Avila S, Coronel J, Charco E, Bojalil R, Astudillo H, Bazán B, Dueñas-González A. A pilot study of nimotuzumab plus single agent chemotherapy as second- or third-line treatment or more in patients with recurrent, persistent or metastatic cervical cancer. Cancer Biol Ther. 2015;16(5):684-9.

23. Chávez-Tapia NC, Rosso N, Uribe M, Bojalil R, Tiribelli C. Kinetics of the inflammatory response induced by free fatty acid accumulation in hepatocytes. Ann Hepatol. 2013 Jan-2014 Feb;13(1):113-20.

24. Dominguez-Avila N, Ruiz-Castañeda G, González-Ramírez J, Fernandez-Jaramillo N, Escoto J, Sánchez-Muñoz F, Marquez-Velasco R, Bojalil R, Espinosa-Cervantes R, Sánchez F. Over, and underexpression of endothelin 1 and TGF-beta family ligands and receptors in lung tissue of broilers with pulmonary hypertension. Biomed Res Int. 2013;2013:190382. doi: 10.1155/2013/190382.

25. Espinola-Zavaleta N, Criales-Vera S, Herrera V, Soto-Abraham V, Soto ME. Multiimaging assessment of successful surgical treatment of pulmonary artery dilatation and dissection in Marfan syndrome. Eur Heart J Cardiovasc Imaging. 2017 May 1;18(5):607. doi: 10.1093/ehjci/jew340.

26. Espinola-Zavaleta N, Rúan-Díaz JC, Soto ME, Ávila-Vanzzini N, Bracamontes-Castelo G, Avendaño-Pérez L. Subclinical ventricular dysfunction by Speckle Tracking in adult patients with coarctation of the aorta. Gac Med Mex. 2017;153(Supl. 2):S18-S26

27. Espinola-Zavaleta N, Soto ME, Romero-Gonzalez A, Gómez-Puente Ldel C, Muñoz- Castellanos L, Gopal AS, Keirns C, Lupi-Herrera E. Prevalence of Congenital Heart Disease and Pulmonary Hypertension in Down's Syndrome: An Echocardiographic Study. J Cardiovasc Ultrasound. 2015 Jun;23(2):72-7.

28. Espinola-Zavaleta N, Vega A, Basto DM, Alcantar-Fernández AC, Guarner Lans V, Soto ME. Survival and clinical behavior of hypertrophic cardiomyopathy in a latin american cohort in contrast to cohorts from the developed world. J Cardiovasc Ultrasound. 2015 Mar;23(1):20-6.

29. Espinoza Hernández CJ, Lacy Niebla RM, Soto López ME, Kresch Tronik NS, Vega- Memije ME. [Prevalence of metabolic syndrome in patients with psoriasis]. Gac Med Mex. 2014 Jul-Aug;150(4):311-6.

30. Gallegos A, Márquez-Velasco R, Allende R, Gómez-Flores JR, Cázares-Campos I, González-Hermosillo A, Bojalil R, Cárdenas M, Márquez MF. Serum concentrations of nitric oxide and soluble tumor necrosis factor receptor 1 (sTNFR1) in vasovagal syncope: effect of orthostatic challenge. Int J Cardiol. 2013 Sep 1;167(5):2321-2.

31. Gómez-García L, Ramírez-Assad C, Vargas A, Massó F, Sánchez-Muñoz F, Márquez- Velasco R, Amezcua-Guerra LM, Bojalil R. Reduced numbers of circulating CD28- negative CD4+ cells in patients with rheumatoid arthritis chronically treated with abatacept. Int J Rheum Dis. 2013 Aug;16(4):469-71.

32. González-Pacheco H, Amezcua-Guerra LM, Sandoval J, Martínez-Sánchez C, Ortiz- León XA, Peña-Cabral MA, Bojalil R. Prognostic Implications of Serum Albumin Levels in Patients With Acute Coronary Syndromes. Am J Cardiol. 2017 Apr 1;119(7):951-958.

33. González-Pacheco H, Amezcua-Guerra LM, Vazquez-Rangel A, Martínez-Sánchez C, Pérez-Méndez O, Verdejo J, Bojalil R. Levels of High-Density Lipoprotein Cholesterol are Associated With Biomarkers of Inflammation in Patients With Acute Coronary Syndrome. Am J Cardiol. 2015 Dec 1;116(11):1651-7.

34. González-Pacheco H, Eid-Lidt G, Piña-Reyna Y, Amezcua-Guerra LM, Aldana- Sepúlveda N, Martínez-Sánchez C. Acute left main coronary artery thrombosis as the first manifestation of systemic lupus erythematosus and catastrophic antiphospholipid syndrome. Am J Emerg Med. 2014 Feb;32(2):197.e3-5.

35. Gutiérrez-Vidal R, Vega-Badillo J, Reyes-Fermín LM, Hernández-Pérez HA, Sánchez- Muñoz F, López-Álvarez GS, Larrieta-Carrasco E, Fernández-Silva I, Méndez-Sánchez N, Tovar AR, Villamil-Ramírez H, Mejía-Domínguez AM, Villarreal-Molina T, Hernández- Pando R, Campos-Pérez F, Aguilar-Salinas CA, Canizales-Quinteros S. SFRP5 hepatic expression is associated with non-alcoholic liver disease in morbidly obese women. Ann Hepatol. 2015 Sep-Oct;14(5):666-74.

36. Hernandez ME, Martinez-Mota L, Salinas C, Marquez-Velasco R, Hernandez-Chan NG, Morales-Montor J, Pérez-Tapia M, Streber ML, Granados-Camacho I, Becerril E, Javier BH, Pavón L. Chronic stress induces structural alterations in splenic lymphoid tissue that are associated with changes in corticosterone levels in wistar-kyoto rats. Biomed Res Int. 2013;2013:868742.

37. Hernandez ME, Mendieta D, Pérez-Tapia M, Bojalil R, Estrada-Garcia I, Estrada-Parra S, Pavón L. Effect of selective serotonin reuptake inhibitors and immunomodulator on cytokines levels: an alternative therapy for patients with major depressive disorder. Clin Dev Immunol. 2013;2013:267871. doi: 10.1155/2013/267871.

38. Hernández-Díaz A, Arana-Martínez JC, Carbó R, Espinosa-Cervantes R, Sánchez- Muñoz F. [Omentin: Role in insulin resistance, inflammation and cardiovascular protection]. Arch Cardiol Mex. 2016 Jul-Sep;86(3):233-43.

39. Higuera V, Amezcua-Guerra LM, Montoya H, Massó F, Patlán M, Paez A, Varela E, Rodríguez-Galicia V, Silveira LH. Association of Nail Dystrophy With Accrued Damage and Capillaroscopic Abnormalities in Systemic Lupus Erythematosus. J Clin Rheumatol. 2016 Jan;22(1):13-8.

40. Higuera-Ortiz V, Mora-Arias T, Castillo-Martinez D, Amezcua-Guerra LM. Anti-Ro/SSA antibodies are associated with severe mitral valve regurgitation in patients with systemic lupus erythematosus. Mod Rheumatol. 2017 May;27(3):476-480.

41. Huang F, Del-Río-Navarro BE, Torres-Alcántara S, Pérez-Ontiveros JA, Ruiz-Bedolla E, Saucedo-Ramírez OJ, Villafaña S, Sánchez Muñoz F, Bravo G, Hong E. Adipokines, asymmetrical dimethylarginine, and pulmonary function in adolescents with asthma and obesity. J Asthma. 2017 Mar;54(2):153-161.

42. Hübbe-Tena C, Gallegos-Nava S, Márquez-Velasco R, Castillo-Martínez D, Vargas- Barrón J, Sandoval J, Amezcua-Guerra LM. Pulmonary hypertension in systemic lupus erythematosus: echocardiography-based definitions predict 6-year survival. Rheumatology (Oxford). 2014 Jul;53(7):1256-63.

43. Huesca-Gómez C, Soto ME, Castrejón-Téllez V, Pérez-Méndez O, Gamboa R. PON1 gene polymorphisms and plasma PON1 activities in Takayasu's arteritis disease. Immunol Lett. 2013 Apr;152(1):77-82.

44. Larrieta-Carrasco E, Acuña-Alonzo V, Velázquez-Cruz R, Barquera-Lozano R, León- Mimila P, Villamil-Ramírez H, Menjivar M, Romero-Hidalgo S, Méndez-Sánchez N, Cárdenas V, Bañuelos-Moreno M, Flores YN, Quiterio M, Salmerón J, Sánchez-Muñoz F, Villarreal-Molina T, Aguilar-Salinas CA, Canizales-Quinteros S. PNPLA3 I148M polymorphism is associated with elevated alanine transaminase levels in Mexican Indigenous and Mestizo populations. Mol Biol Rep. 2014 Jul;41(7):4705-11.

45. Larrieta-Carrasco E, León-Mimila P, Villarreal-Molina T, Villamil-Ramírez H, Romero- Hidalgo S, Jacobo-Albavera L, Gutiérrez-Vidal R, López-Contreras BE, Guillén-Pineda LE, Sánchez-Muñoz F, Bojalil R, Mejía-Domínguez AM, Méndez-Sánchez N, Domínguez-López A, Aguilar-Salinas CA, Canizales-Quinteros S. Association of the I148M/PNPLA3 variant with elevated alanine transaminase levels in normal-weight and overweight/obese Mexican children. Gene. 2013 May 15;520(2):185-8.

46. Loaiza-Félix J, Moreno-Ramírez M, Pérez-García FL, Jiménez-Rojas V, Sánchez-Muñoz F, Amezcua-Guerra ML. Serum levels of adipokines in patients with idiopathic inflammatory myopathies: a pilot study. Rheumatol Int. 2017 Aug;37(8):1341-1345.

47. López-Cano DJ, Cadena-Sandoval D, Beltrán-Ramírez O, Barbosa-Cobos RE, Sánchez-Muñoz F, Amezcua-Guerra LM, Juárez-Vicuña Y, Aguilera-Cartas MC, Moreno J, Bautista-Olvera J, Valencia-Pacheco G, López-Villanueva RF, Ramírez-Bello J. The PTPN22 R263Q polymorphism confers protection against systemic lupus erythematosus and rheumatoid arthritis, while PTPN22 R620W confers susceptibility to Graves' disease in a Mexican population. Inflamm Res. 2017 Sep;66(9):775-781.

48. López-Contreras BE, Morán-Ramos S, Villarruel-Vázquez R, Macías-Kauffer L, Villamil- Ramírez H, León-Mimila P, Vega-Badillo J, Sánchez-Muñoz F, Llanos-Moreno LE, Canizalez-Román A, Del Río-Navarro B, Ibarra-González I, Vela-Amieva M,Villarreal- Molina T, Ochoa-Leyva A, Aguilar-Salinas CA, Canizales-Quinteros S. Composition of gut microbiota in obese and normal-weight Mexican school-age children and its association with metabolic traits. Pediatr Obes. 2017 Dec 5. doi: 10.1111/ijpo.12262.

49. Martínez-Lavín M, Amezcua-Guerra L. Erratum to: Serious adverse events after HPV vaccination: a critical review of randomized trials and post-marketing case series. Clin Rheumatol. 2017 Oct;36(10):2397.

50. Martínez-Lavín M, Amezcua-Guerra L. Serious adverse events after HPV vaccination: a critical review of randomized trials and post-marketing case series. Clin Rheumatol. 2017 Oct;36(10):2169-2178.

51. Meléndez-Ramírez G, de Micheli A, Soto ME, Meave-González A, Kimura-Hayama E, Alcántara M, González-Pacheco H. Agreement between ST elevation and late enhancement evaluated by MRI in patients with acute myocarditis. J Electrocardiol. 2014 Mar-Apr;47(2):212-8.

52. Meléndez-Ramírez G, Vera-Urquiza R, Soto ME. Interventricular septum involvement with complete atrioventricular block as first manifestation in Takayasu arteritis. J Nucl Cardiol. 2018 Jan 16. doi: 10.1007/s12350-017-1165-8.

53. Mijangos-Vázquez R, Patiño-Bahena E, Martínez-García A, Herrera J, Calderón- Colmenero J, Buendía-Hernández A, Soto-López ME. [Aberrant right subclavian artery in children examined at the National Institute of Cardiology Ignacio Chavez (1992- 2012)]. Arch Cardiol Mex. 2014 Jul-Sep;84(3):155-61.

54. Mijangos-Vázquez R, Zabal-Cerdeira C, García-Montes JA, Calderón-Colmenero J, Buendía-Hernández A, Soto-López ME. [Stent broncoplasty in left main bronchus in a patient with absent pulmonary valve syndrome. A case report]. Arch Cardiol Mex. 2016 Jul-Sep;86(3):289-91.

55. Mora-Ramírez M, Estevez-Garcia IO, Irigoyen-Camacho ME, Bojalil R, Gonzalez-Pacheco H, Amezcua-Guerra LM. Hyperuricemia on Admission Predicts Short-Term Mortality due to Myocardial Infarction in a Population with High Prevalence of Cardiovascular Risk Factors. Rev Invest Clin. 2017 Sep-Oct;69(5):247-253.

56. Mora-Ramírez M, González-Pacheco H, Amezcua-Guerra LM. Stents Coated With Mammalian Target of Rapamycin Inhibitors (mTOR) Appear to Be the Best Choice in Patients With Antiphospholipid Syndrome and Myocardial Infarction. J Clin Rheumatol. 2016 Aug;22(5):281.

57. Mora-Ramirez M, Gonzalez-Pacheco H, Amezcua-Guerra LM. The Impact of Primary Antiphospholipid Syndrome on Long-term Cardiovascular Outcomes After Percutaneous Coronary Intervention and Stenting in Patients With Myocardial Infarction. J Clin Rheumatol. 2017 Dec 12. doi: 10.1097/RHU.0000000000000651.

58. Núñez-Enríquez JC, Bárcenas-López DA, Hidalgo-Miranda A, Jiménez-Hernández E, Bekker-Méndez VC, Flores-Lujano J, Solis-Labastida KA, Martínez-Morales GB, Sánchez-Muñoz F, Espinoza-Hernández LE, Velázquez-Aviña MM, Merino-Pasaye LE, García Velázquez AJ, Pérez-Saldívar ML, Mojica-Espinoza R, Ramírez-Bello J, Jiménez-Morales S, Mejía-Aranguré JM; MIGICCL. Gene Expression Profiling of Acute Lymphoblastic Leukemia in Children with Very Early Relapse. Arch Med Res. 2016 Nov;47(8):644-655.

59. Ortega-Hernández J, Springall R, Sánchez-Muñoz F, Arana-Martinez JC, González- Pacheco H, Bojalil R. Acute coronary syndrome and acute kidney injury: role of inflammation in worsening renal function. BMC Cardiovasc Disord. 2017 Jul 26;17(1):202. doi: 10.1186/s12872-017-0640-0

60. Ortiz Segura MDC, Del Río Navarro BE, Rodríguez Espino BA, Marchat LA, Sánchez- Muñoz F, Villafaña S, Hong E, Meza-Cuenca F, Mailloux Salinas P, Bolaños-Jiménez F, Zambrano E, Arredondo-López AA, Bravo G, Huang F. Abnormality of adipokines and endothelial dysfunction in Mexican obese adolescents with insulin resistance. Endocr Res. 2017 Aug;42(3):252-259. 28318332.

61. Pascual Ramos V, Medrano Ramírez G, Solís Vallejo E, Bernard Medina AG, Flores Alvarado DE, Portela Hernández M, Andrade Ortega L, Vera Lastra O, Espinosa Morales R, Miranda Limón JM, Maldonado Velázquez Mdel R, Jara Quezada LJ, Amezcua Guerra LM, López Zepeda J, Saavedra Salinas MÁ, Arce Salinas CA. Performance of an objective structured clinical examination in a national certification process of trainees in rheumatology. Reumatol Clin. 2015 Jul-Aug;11(4):215-20.

62. Pascual-Ramos V, Flores-Alvarado DE, Portela-Hernández M, Maldonado-Velázquez MDR, Amezcua-Guerra LM, López-Zepeda J, Álvarez E, Rubio N, Lastra OV, Saavedra MÁ, Arce-Salinas CA; A.C. Consejo Mexicano de Reumatología. Communication Skills in Candidates for Accreditation in Rheumatology Are Correlated With Candidate's Performance in the Objective Structured Clinical Examination. Reumatol Clin. 2017 Jul 26. pii: S1699-258X(17)30139-0. doi: 10.1016/j.reuma.2017.06.007.

63. Pascual-Ramos V, Guilaisne Bernard-Medina A, Flores-Alvarado DE, Portela- Hernández M, Maldonado-Velázquez MD, Jara-Quezada LJ, Amezcua-Guerra LM, Rubio-Judith López-Zepeda NE, Álvarez-Hernandez E, Saavedra MÁ, Arce-Salinas CA; Consejo Mexicano de Reumatología (CMR). The method used to set the pass mark in an objective structured clinical examination defines the performance of candidates for certification as rheumatologists. Reumatol Clin. 2017 Feb 1. pii: S1699-258X(16)30163- 2. doi: 10.1016/j.reuma.2016.11.007.

64. Patlán M, Sánchez-Muñoz F, Amezcua-Guerra LM, Granados A, Páez A, Massó F, Mejía AM, Soster A, Bojalil R, Pavón L, Jiménez-Zamudio LA, Márquez-Velasco R. Effect of fresh frozen plasma on the in vitro activation of U937 monocytes: a potential role for the age of blood donors and their underlying cytokine profile. Biol Res. 2017 Dec 21;50(1):42. doi: 10.1186/s40659-017-0146-3.

65. Roberto MV, Jorge Manuel GA, José Antonio GM, Carlos ZC, Alfonso BH, María Elena SL. Right ventricle apical diverticulum associated with a congenital cardiopathy and a mid line abdominal malformation. A case report. Arch Cardiol Mex. 2016 Jan- Mar;86(1):92-4.

66. Rodríguez-Cruz M, Coral-Vázquez RM, Hernández-Stengele G, Sánchez R, Salazar E, Sanchez-Muñoz F, Encarnación-Guevara S, Ramírez-Salcedo J. Identification of putative ortholog gene blocks involved in gestant and lactating mammary gland development: a rodent cross-species microarray transcriptomics approach. Int J Genomics. 2013;2013:624681. doi: 10.1155/2013/624681.

67. Rodriguez-Hernandez A, Elena Soto M, Vargas-Barron J, Marquez R, Bojalil-Parra R, Perez-Torres I, Luis Salas-Pacheco J, Jimenez-Rojas V, Antonio Arias-Godinez J, Guarner-Lans V. Immunologic Responses in Biological and Mechanical Valve Prostheses: Inflammation and Functionality Are Not Always Related. J Heart Valve Dis. 2017 May;26(3):334-343.

68. Romero-Nava R, Rodriguez JE, Reséndiz-Albor AA, Sánchez-Muñoz F, Ruiz-Hernandéz A, Huang F, Hong E, Villafaña S. Changes in protein and gene expression of angiotensin II receptors (AT1 and AT2) in aorta of diabetic and hypertensive rats. Clin Exp Hypertens. 2016;38(1):56-62.

69. Romero-Nava R, Zhou DS, García N, Ruiz-Hernández A, Si YC, Sánchez-Muñoz F, Huang F, Hong E, Villafaña S. Evidence of alterations in the expression of orphan receptors GPR26 and GPR39 due to the etiology of the metabolic syndrome. J Recept Signal Transduct Res. 2017 Aug;37(4):422-429.

70. Rubio-Ruiz ME, Pérez-Torres I, Soto ME, Pastelín G, Guarner-Lans V. Aging in blood vessels. Medicinal agents FOR systemic arterial hypertension in the elderly. Ageing Res Rev. 2014 Nov;18:132-47. doi: 10.1016/j.arr.2014.10.001.

71. Ruiz-Castañeda G, Dominguez-Avila N, González-Ramírez J, Fernandez-Jaramillo N, Escoto-Herrera J, Sánchez-Muñoz F, Amezcua-Guerra LM, Marquez-Velasco R, Bojalil R, Espinosa-Cervantes R, Sánchez F. Myocardial expression of transforming growth factor beta family and endothelin-1 in the progression from heart failure to ascites in broilers with cold-induced pulmonary hypertension. J Recept Signal Transduct Res. 2015 Nov 13:1-6.

72. Ruiz-Hernández A, Sánchez-Muñoz F, Rodriguez J, Calderón-Zamora L, Romero-Nava R, Huang F, Hong E, Villafaña S. Expression of orphan receptors GPR22 and GPR162 in streptozotocin-induced diabetic rats. J Recept Signal Transduct Res. 2015 Feb;35(1):46-53.

73. Sánchez-Muñoz F, Amezcua-Guerra LM, Macías-Palacios M, Márquez-Velasco R, Bojalil R. Vanin-1 as a potential novel biomarker for active nephritis in systemic lupus erythematosus. Lupus. 2013 Mar;22(3):333-5.

74. Sixtos-Alonso MS, Avalos-Martinez R, Sandoval-Salas R, Dehesa-Violante M, García- Juarez I, Chávez-Ayala A, Domínguez-López A, Vargas-Vorácková F, Toapanta- Yanchapaxi L, Amezcua-Guerra LM, Uribe M, Sánchez-Ávila JF. A genetic variant in the interleukin 28B gene as a major predictor for sustained virologic response in chronic hepatitis C virus infection. Arch Med Res. 2015 Aug;46(6):448-53.

75. Soto López ME, Gamboa Ávila R, Hernández E, Huesca-Gómez C, Castrejón-Téllez V, Pérez-Méndez O, Reyes PA, Fragoso-Lona JM, Vargas-Alarcón G, Cruz-Robles D. The interleukin-1 gene cluster polymorphisms are associated with Takayasu's arteritis in Mexican patients. J Interferon Cytokine Res. 2013 Jul;33(7):369-75.

76. Soto ME, Hernández-Becerril N, Perez-Chiney AC, Hernández-Rizo A, Telich-Tarriba JE, Juárez-Orozco LE, Melendez G, Bojalil R. Predictive value of antinuclear antibodies in autoimmune diseases classified by clinical criteria: Analytical study in a specialized health institute, one year follow-up. Results Immunol. 2013 Nov 9;5:13-22.

77. Soto ME, Iturriaga Hernández AV, Guarner Lans V, Zuñiga-Muñoz A, Aranda Fraustro A, Velázquez Espejel R, Pérez-Torres I. Participation of oleic acid in the formation of the aortic aneurysm in Marfan syndrome patients. Prostaglandins Other Lipid Mediat. 2016 Mar;123:46-55.

78. Soto ME, Reyes-Villatoro MA, Márquez R, Cardoso G, Posadas-Sánchez R, Juárez- Orozco LE. Evaluation and analysis of plasma soluble adhesion molecules in patients with coronary ectasia and atherosclerotic coronary artery disease. Arch Med Res. 2014 Aug;45(6):478-83.

79. Soto ME, Salas JL, Vargas-Barron J, Marquez R, Rodriguez-Hernandez A, Bojalil-Parra R, Pérez-Torres I, Guarner-Lans V. Pre- and post-surgical evaluation of the inflammatory response in patients with aortic stenosis treated with different types of prosthesis. BMC Cardiovasc Disord. 2017 Apr 14;17(1):100. doi: 10.1186/s12872-017- 0526-1.

80. Soto ME, Soria-Castro E, Lans VG, Ontiveros EM, Mejía BI, Hernandez HJ, García RB, Herrera V, Pérez-Torres I. Analysis of oxidative stress enzymes and structural and functional proteins on human aortic tissue from different aortopathies. Oxid Med Cell Longev. 2014;2014:760694. doi: 10.1155/2014/760694.

81. Soto ME, Zuñiga-Muñoz A, Guarner Lans V, Duran-Hernández EJ, Pérez-Torres I. Infusion of Hibiscus sabdariffa L. Modulates Oxidative Stress in Patients with Marfan Syndrome. Mediators Inflamm. 2016;2016:8625203. doi: 10.1155/2016/8625203.

82. Springall R, Amezcua-Guerra LM, Gonzalez-Pacheco H, Furuzawa-Carballeda J, Gomez-Garcia L, Marquez-Velasco R, Mejía-Domínguez AM, Cossío-Aranda J, Martínez-Sánchez C, Bojalil R. Interferon-gamma increases the ratio of matrix metalloproteinase-9/tissue inhibitor of metalloproteinase-1 in peripheral monocytes from patients with coronary artery disease. PLoS One. 2013 Aug 12;8(8):e72291. doi: 10.1371/journal.pone.0072291.

83. Terrazas LI, Sánchez-Muñoz F, Pérez-Miranda M, Mejía-Domínguez AM, Ledesma-Soto Y, Bojalil R, Gómez-García L. Helminth excreted/secreted antigens repress expression of LPS-induced Let-7i but not miR-146a and miR-155 in human dendritic cells. Biomed Res Int. 2013;2013:972506. doi: 10.1155/2013/972506.

84. Vargas-Alarcón G, Posadas-Romero C, Villarreal-Molina T, Alvarez-León E, Angeles- Martinez J, Soto ME, Monroy-Muñoz I, Juárez JG, Sánchez-Ramírez CJ, Ramirez-Bello J, Ramírez-Fuentes S, Fragoso JM, Rodríguez-Pérez JM. The (G>A) rs11573191 polymorphism of PLA2G5 gene is associated with premature coronary artery disease in the Mexican Mestizo population: the genetics of atherosclerotic disease Mexican study. Biomed Res Int. 2014;2014:931361. doi: 10.1155/2014/931361.

85. Vega-Badillo J, Gutiérrez-Vidal R, Hernández-Pérez HA, Villamil-Ramírez H, León- Mimila P, Sánchez-Muñoz F, Morán-Ramos S, Larrieta-Carrasco E, Fernández-Silva I, Méndez-Sánchez N, Tovar AR, Campos-Pérez F, Villarreal-Molina T, Hernández-Pando R, Aguilar-Salinas CA, Canizales-Quinteros S. Hepatic miR-33a/miR-144 and their target gene ABCA1 are associated with steatohepatitis in morbidly obese subjects. Liver Int. 2016 Sep;36(9):1383-91.

86. Villamil-Ramírez H, León-Mimila P, Macias-Kauffer LR, Canizalez-Román A, Villalobos- Comparán M, León-Sicairos N, Vega-Badillo J, Sánchez-Muñoz F, López-Contreras B, Morán-Ramos S, Villarreal-Molina T, Zurita LC, Campos-Pérez F, Huertas-Vazquez A, Bojalil R, Romero-Hidalgo S, Aguilar-Salinas CA, Canizales-Quinteros S. A combined linkage and association strategy identifies a variant near the GSTP1 gene associated with BMI in the Mexican population. J Hum Genet. 2017 Mar;62(3):413-418.

87. Zúñiga-Muñoz AM, Pérez-Torres I, Guarner-Lans V, Núñez-Garrido E, Velázquez Espejel R, Huesca-Gómez C, Gamboa-Ávila R, Soto ME. Glutathione system participation in thoracic aneurysms from patients with Marfan syndrome. Vasa. 2017 May;46(3):177-186.